Matrix Metalloproteinases are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington’s Disease

Proteolytic cleavage of huntingtin (Htt) is known to be a key event in the pathogenesis of Huntington’s disease (HD). Our understanding of proteolytic processing of Htt has thus far focused on the cysteine protease families of caspases and calpains. Identifying critical protease families involved in...

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Bibliographic Details
Main Authors: Miller, John P., Holcomb, Jennifer, Al-Ramahi, Ismael, de Haro, Maria, Gafni, Juliette, Zhang, Ningzhe, Kim, Eugene, Sanhueza, Mario, Torcassi, Cameron, Kwak, Seung, Botas, Juan, Hughes, Robert E., Ellerby, Lisa M.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098887/
https://ncbi.nlm.nih.gov/pubmed/20670829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.06.021
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