Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein with several consensus caspase cleavage sites. Despite the identification of htt fragments in the brain, it has not been shown conclusively that htt is cleaved by caspases in vivo. Furthermore, no stud...

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Publicado no:J Neurosci
Main Authors: Wellington, Cheryl L., Ellerby, Lisa M., Gutekunst, Claire-Anne, Rogers, Danny, Warby, Simon, Graham, Rona K., Loubser, Odell, van Raamsdonk, Jeremy, Singaraja, Roshni, Yang, Yu-Zhou, Gafni, Juliette, Bredesen, Dale, Hersch, Steven M., Leavitt, Blair R., Roy, Sophie, Nicholson, Donald W., Hayden, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758089/
https://ncbi.nlm.nih.gov/pubmed/12223539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-18-07862.2002
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