Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein with several consensus caspase cleavage sites. Despite the identification of htt fragments in the brain, it has not been shown conclusively that htt is cleaved by caspases in vivo. Furthermore, no stud...

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Bibliografski detalji
Izdano u:J Neurosci
Glavni autori: Wellington, Cheryl L., Ellerby, Lisa M., Gutekunst, Claire-Anne, Rogers, Danny, Warby, Simon, Graham, Rona K., Loubser, Odell, van Raamsdonk, Jeremy, Singaraja, Roshni, Yang, Yu-Zhou, Gafni, Juliette, Bredesen, Dale, Hersch, Steven M., Leavitt, Blair R., Roy, Sophie, Nicholson, Donald W., Hayden, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2002
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ARTICLE
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758089/
https://ncbi.nlm.nih.gov/pubmed/12223539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-18-07862.2002
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