Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.

A unifying feature of the CAG expansion diseases is the formation of intracellular aggregates composed of the mutant polyglutamine-expanded protein. Despite the presence of aggregates in affected patients, the precise relationship between aggregates and disease pathogenesis is unresolved. Results fr...

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Detalhes bibliográficos
Main Authors: Hackam, A S, Hodgson, J G, Singaraja, R, Zhang, T, Gan, L, Gutekunst, C A, Hersch, S M, Hayden, M R
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1692613/
https://ncbi.nlm.nih.gov/pubmed/10434304
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