Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein with several consensus caspase cleavage sites. Despite the identification of htt fragments in the brain, it has not been shown conclusively that htt is cleaved by caspases in vivo. Furthermore, no stud...

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Publicado en:J Neurosci
Autores principales: Wellington, Cheryl L., Ellerby, Lisa M., Gutekunst, Claire-Anne, Rogers, Danny, Warby, Simon, Graham, Rona K., Loubser, Odell, van Raamsdonk, Jeremy, Singaraja, Roshni, Yang, Yu-Zhou, Gafni, Juliette, Bredesen, Dale, Hersch, Steven M., Leavitt, Blair R., Roy, Sophie, Nicholson, Donald W., Hayden, Michael R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758089/
https://ncbi.nlm.nih.gov/pubmed/12223539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-18-07862.2002
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