Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

BACKGROUND: Huntington disease (HD) is an adult onset neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. Htt function is essential for embryonic survival as well as normal function during the postnatal period. In addition to having roles in transcription...

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Autors principals: Van Raamsdonk, Jeremy M, Pearson, Jacqueline, Murphy, Zoe, Hayden, Michael R, Leavitt, Blair R
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762017/
https://ncbi.nlm.nih.gov/pubmed/17147801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-7-80
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