Cognitive Dysfunction Precedes Neuropathology and Motor Abnormalities in the YAC128 Mouse Model of Huntington's Disease

Huntington's disease (HD) is an adult-onset neurodegenerative disorder involving motor dysfunction, cognitive deficits, and psychiatric disturbances that result from underlying striatal and cortical dysfunction and neuropathology. The YAC128 mouse model of HD reproduces both the motor deficits...

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Vydáno v:J Neurosci
Hlavní autoři: Van Raamsdonk, Jeremy M., Pearson, Jacqueline, Slow, Elizabeth J., Hossain, Sazzad M., Leavitt, Blair R., Hayden, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Neurobiology of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724951/
https://ncbi.nlm.nih.gov/pubmed/15843620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0590-05.2005
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