Cognitive Dysfunction Precedes Neuropathology and Motor Abnormalities in the YAC128 Mouse Model of Huntington's Disease

Huntington's disease (HD) is an adult-onset neurodegenerative disorder involving motor dysfunction, cognitive deficits, and psychiatric disturbances that result from underlying striatal and cortical dysfunction and neuropathology. The YAC128 mouse model of HD reproduces both the motor deficits...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Van Raamsdonk, Jeremy M., Pearson, Jacqueline, Slow, Elizabeth J., Hossain, Sazzad M., Leavitt, Blair R., Hayden, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2005
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724951/
https://ncbi.nlm.nih.gov/pubmed/15843620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0590-05.2005
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