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BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice
Huntington's disease (HD) is caused by an expansion of the polyglutamine tract at the N terminus of huntingtin. This mutation reduces levels of BDNF in the striatum, likely by inhibiting cortical Bdnf gene expression and anterograde transport of BDNF from the cerebral cortex to the striatum. Su...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2989389/ https://ncbi.nlm.nih.gov/pubmed/21048129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1637-10.2010 |
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