Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

BACKGROUND: Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum. Mutant HTT expression causes dysfunctional cortico-striatal (CS) transmission, loss of...

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Publicat a:BMC Biol
Autors principals: Schmidt, Mandi E., Buren, Caodu, Mackay, James P., Cheung, Daphne, Dal Cengio, Louisa, Raymond, Lynn A., Hayden, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020351/
https://ncbi.nlm.nih.gov/pubmed/29945611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0526-3
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