DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease

Huntington disease (HD) is a devastating neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. Disrupted cortico-striatal transmission is an early event that contributes to neuronal spine and synapse dysfunction primarily in striatal medium spiny neurons, the most vulne...

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Udgivet i:Front Cell Neurosci
Main Authors: Schmidt, Mandi E., Caron, Nicholas S., Aly, Amirah E., Lemarié, Fanny L., Dal Cengio, Louisa, Ko, Yun, Lazic, Nikola, Anderson, Lisa, Nguyen, Betty, Raymond, Lynn A., Hayden, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Cellular Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674490/
https://ncbi.nlm.nih.gov/pubmed/33250715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.590569
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