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Brain-derived Neurotrophic Factor Over-expression in the Forebrain Ameliorates Huntington’s Disease Phenotypes in Mice

Huntington’s disease (HD), a dominantly inherited neurodegenerative disorder characterized by relatively selective degeneration of striatal neurons, is caused by an expanded polyglutamine tract of the huntingtin protein. The huntingtin mutation reduces levels of brain-derived neurotrophic factor (BD...

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Detalhes bibliográficos
Main Authors: Gharami, Kusumika, Xie, Yuxiang, An, Juan Ji, Tonegawa, Susumu, Xu, Baoji
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377033/
https://ncbi.nlm.nih.gov/pubmed/18086127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05137.x
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