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Brain-derived Neurotrophic Factor Over-expression in the Forebrain Ameliorates Huntington’s Disease Phenotypes in Mice
Huntington’s disease (HD), a dominantly inherited neurodegenerative disorder characterized by relatively selective degeneration of striatal neurons, is caused by an expanded polyglutamine tract of the huntingtin protein. The huntingtin mutation reduces levels of brain-derived neurotrophic factor (BD...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2377033/ https://ncbi.nlm.nih.gov/pubmed/18086127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05137.x |
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