Neural stem cells derived from the developing forebrain of YAC128 mice exhibit pathological features of Huntington’s disease

OBJECTIVES: Huntington's disease (HD) is a devastating neurodegenerative disease caused by polyglutamine (polyQ) expansion in the huntingtin (HTT) gene. Mutant huntingtin (mHTT) is the main cause of HD and is associated with impaired mitochondrial dynamics, ubiquitin‐proteasome system and autop...

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Bibliographic Details
Published in:Cell Prolif
Main Authors: Li, Endan, Park, Hee Ra, Hong, Chang Pyo, Kim, Younghoon, Choi, Jiwoo, Lee, Suji, Park, Hyun Jung, Lee, Bomi, Kim, Tae Aug, Kim, Seong Jin, Kim, Hyun Sook, Song, Jihwan
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574873/
https://ncbi.nlm.nih.gov/pubmed/32865873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12893
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