Cognitive Dysfunction Precedes Neuropathology and Motor Abnormalities in the YAC128 Mouse Model of Huntington's Disease

Huntington's disease (HD) is an adult-onset neurodegenerative disorder involving motor dysfunction, cognitive deficits, and psychiatric disturbances that result from underlying striatal and cortical dysfunction and neuropathology. The YAC128 mouse model of HD reproduces both the motor deficits...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Van Raamsdonk, Jeremy M., Pearson, Jacqueline, Slow, Elizabeth J., Hossain, Sazzad M., Leavitt, Blair R., Hayden, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2005
Teme:
Neurobiology of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724951/
https://ncbi.nlm.nih.gov/pubmed/15843620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0590-05.2005
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