Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease

Huntington disease (HD) is a neurodegenerative disorder caused by an expanded CAG tract in the HD gene. Polyglutamine expansion of huntingtin (htt) results in early, progressive loss of medium spiny striatal neurons, as well as cortical neurons that project to the striatum. Excitotoxicity has been p...

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Main Authors: Graham, Rona K., Pouladi, Mahmoud A., Joshi, Prasad, Lu, Ge, Deng, Yu, Wu, Nan-Ping, Figueroa, Bryan E., Metzler, Martina, André, Véronique M., Slow, Elizabeth J., Raymond, Lynn, Friedlander, Robert, Levine, Michael S., Leavitt, Blair R., Hayden, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729178/
https://ncbi.nlm.nih.gov/pubmed/19228972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5473-08.2009
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