Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease

Huntington disease (HD) is a neurodegenerative disorder caused by an expanded CAG tract in the HD gene. Polyglutamine expansion of huntingtin (htt) results in early, progressive loss of medium spiny striatal neurons, as well as cortical neurons that project to the striatum. Excitotoxicity has been p...

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主要な著者: Graham, Rona K., Pouladi, Mahmoud A., Joshi, Prasad, Lu, Ge, Deng, Yu, Wu, Nan-Ping, Figueroa, Bryan E., Metzler, Martina, André, Véronique M., Slow, Elizabeth J., Raymond, Lynn, Friedlander, Robert, Levine, Michael S., Leavitt, Blair R., Hayden, Michael R.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2009
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729178/
https://ncbi.nlm.nih.gov/pubmed/19228972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5473-08.2009
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