Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease

Huntington disease (HD) is a neurodegenerative disorder caused by an expanded CAG tract in the HD gene. Polyglutamine expansion of huntingtin (htt) results in early, progressive loss of medium spiny striatal neurons, as well as cortical neurons that project to the striatum. Excitotoxicity has been p...

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Autors principals: Graham, Rona K., Pouladi, Mahmoud A., Joshi, Prasad, Lu, Ge, Deng, Yu, Wu, Nan-Ping, Figueroa, Bryan E., Metzler, Martina, André, Véronique M., Slow, Elizabeth J., Raymond, Lynn, Friedlander, Robert, Levine, Michael S., Leavitt, Blair R., Hayden, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729178/
https://ncbi.nlm.nih.gov/pubmed/19228972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5473-08.2009
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