Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

BACKGROUND: Huntington disease (HD) is an adult onset neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. Htt function is essential for embryonic survival as well as normal function during the postnatal period. In addition to having roles in transcription...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Van Raamsdonk, Jeremy M, Pearson, Jacqueline, Murphy, Zoe, Hayden, Michael R, Leavitt, Blair R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2006
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762017/
https://ncbi.nlm.nih.gov/pubmed/17147801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-7-80
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