Identification and Evaluation of Novel Small Molecule Pan-Caspase Inhibitors in Huntington’s Disease Models

Huntington’s Disease (HD) is characterized by a mutation in the huntingtin gene encoding an expansion of glutamine repeats on the N-terminus of the huntingtin (Htt) protein. Numerous studies have identified Htt proteolysis as a critical pathological event in post mortem human tissue and mouse HD mod...

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Hlavní autoři: Leyva, Melissa J., DeGiacomo, Francesco, Kaltenbach, Linda S., Holcomb, Jennifer, Zhang, Ningzhe, Gafni, Juliette, Park, Hyunsun, Lo, Donald C., Salvesen, Guy S., Ellerby, Lisa M., Ellman, Jonathan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035168/
https://ncbi.nlm.nih.gov/pubmed/21095569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.08.014
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