Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo

The cascade of events that lead to cognitive decline, motor deficits, and psychiatric symptoms in patients with Huntington disease (HD) is triggered by a polyglutamine expansion in the N-terminal region of the huntingtin (HTT) protein. A significant mechanism in HD is the generation of mutant HTT fr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: O'Brien, Robert, DeGiacomo, Francesco, Holcomb, Jennifer, Bonner, Akilah, Ring, Karen L., Zhang, Ningzhe, Zafar, Khan, Weiss, Andreas, Lager, Brenda, Schilling, Birgit, Gibson, Bradford W., Chen, Sylvia, Kwak, Seung, Ellerby, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521048/
https://ncbi.nlm.nih.gov/pubmed/26025364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.623561
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