Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation

Cleavage of mutant huntingtin (HTT) is an essential process in Huntington’s disease (HD), an inherited neurodegenerative disorder. Cleavage generates N-ter fragments that contain the polyQ stretch and whose nuclear toxicity is well established. However, the functional defects induced by cleavage of...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: El-Daher, Marie-Thérèse, Hangen, Emilie, Bruyère, Julie, Poizat, Ghislaine, Al-Ramahi, Ismael, Pardo, Raul, Bourg, Nicolas, Souquere, Sylvie, Mayet, Céline, Pierron, Gérard, Lévêque-Fort, Sandrine, Botas, Juan, Humbert, Sandrine, Saudou, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585462/
https://ncbi.nlm.nih.gov/pubmed/26165689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490808
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