Smaug/SAMD4A Restores Translational Activity of CUGBP1 and Suppresses CUG-Induced Myopathy

We report the identification and characterization of a previously unknown suppressor of myopathy caused by expansion of CUG repeats, the mutation that triggers Myotonic Dystrophy Type 1 (DM1). We screened a collection of genes encoding RNA–binding proteins as candidates to modify DM1 pathogenesis us...

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Detaylı Bibliyografya
Asıl Yazarlar: de Haro, Maria, Al-Ramahi, Ismael, Jones, Karlie R., Holth, Jerrah K., Timchenko, Lubov T., Botas, Juan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630084/
https://ncbi.nlm.nih.gov/pubmed/23637619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003445
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