Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells

The purpose of this study was to investigate the role of the mutant CUGn RNA in the induction of stress in type 1 myotonic dystrophy (DM1) cells and in the stress-mediated inhibition of protein translation in DM1. To achieve our goals, we performed HPLC-based purification of stress granules (SGs), i...

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Detalhes bibliográficos
Main Authors: Huichalaf, Claudia, Sakai, Keiko, Jin, Bingwen, Jones, Karlie, Wang, Guo-Li, Schoser, Benedikt, Schneider-Gold, Christiane, Sarkar, Partha, Pereira-Smith, Olivia M., Timchenko, Nikolai, Timchenko, Lubov
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996918/
https://ncbi.nlm.nih.gov/pubmed/20479119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-151159
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