Expression of RNA CCUG Repeats Dysregulates Translation and Degradation of Proteins in Myotonic Dystrophy 2 Patients

Myotonic dystrophy 2 (DM2) is a multisystem skeletal muscle disease caused by an expansion of tetranucleotide CCTG repeats, the transcription of which results in the accumulation of untranslated CCUG RNA. In this study, we report that CCUG repeats both bind to and misregulate the biological function...

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Detalhes bibliográficos
Main Authors: Salisbury, Elizabeth, Schoser, Benedikt, Schneider-Gold, Christiane, Wang, Guo-Li, Huichalaf, Claudia, Jin, Bingwen, Sirito, Mario, Sarkar, Partha, Krahe, Ralf, Timchenko, Nikolai A., Timchenko, Lubov T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716970/
https://ncbi.nlm.nih.gov/pubmed/19590039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090047
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