Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate

Induction of p21 in senescent human fibroblasts plays a key role in the inactivation of cyclin-dependent kinases and the resulting irreversible growth arrest in the early stages of cell senescence. We found that RNA-binding proteins are critical regulators of p21 during senescence. Two RNA-binding p...

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Hlavní autoři: Iakova, Polina, Wang, Guo-Li, Timchenko, Lubov, Michalak, Marek, Pereira-Smith, Olivia M, Smith, James R, Timchenko, Nikolai A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1271759/
https://ncbi.nlm.nih.gov/pubmed/14726956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600052
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