Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington’s disease mice

por Mégret, Lucile, Nair, Satish Sasidharan, Dancourt, Julia, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado en BMC Bioinformatics (2020)

Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington’s disease mice synchronous to symptoms

por Bigan, Erwan, Sasidharan Nair, Satish, Lejeune, François-Xavier, Fragnaud, Hélissande, Parmentier, Frédéric, Mégret, Lucile, Verny, Marc, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado en Bioinformatics (2020)

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

por Langfelder, Peter, Gao, Fuying, Wang, Nan, Howland, David, Kwak, Seung, Vogt, Thomas F., Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Publicado en PLoS One (2018)

Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

por Megret, Lucile, Gris, Barbara, Sasidharan Nair, Satish, Cevost, Jasmin, Wertz, Mary, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Wilkinson, Hilary, Heiman, Myriam, Neri, Christian
Publicado en eLife (2021)

Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease

por Mielcarek, Michal, Inuabasi, Linda, Bondulich, Marie K., Muller, Thomas, Osborne, Georgina F., Franklin, Sophie A., Smith, Donna L., Neueder, Andreas, Rosinski, Jim, Rattray, Ivan, Protti, Andrea, Bates, Gillian P.
Publicado 2014

Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease

por Plotkin, Joshua L., Day, Michelle, Peterson, Jayms D., Xie, Zhong, Kress, Geraldine J., Rafalovich, Igor, Kondapalli, Jyothisri, Gertler, Tracy S., Flajolet, Marc, Greengard, Paul, Stavarache, Mihaela, Kaplitt, Michael G., Rosinski, Jim, Chan, C. Savio, Surmeier, D. James
Publicado 2014

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

por Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F., Eszes, Marika, Faull, Richard L.M., Curtis, Maurice A., Waldvogel, Henry J., Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V., Coppola, Giovanni, Yang, X. William
Publicado en Aging (Albany NY) (2016)

Transcriptional regulatory networks underlying gene expression changes in Huntington's disease

por Ament, Seth A, Pearl, Jocelynn R, Cantle, Jeffrey P, Bragg, Robert M, Skene, Peter J, Coffey, Sydney R, Bergey, Dani E, Wheeler, Vanessa C, MacDonald, Marcy E, Baliga, Nitin S, Rosinski, Jim, Hood, Leroy E, Carroll, Jeffrey B, Price, Nathan D
Publicado en Mol Syst Biol (2018)

Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice

por Langfelder, Peter, Cantle, Jeffrey P., Chatzopoulou, Doxa, Wang, Nan, Gao, Fuying, Al-Ramahi, Ismael, Lu, Xiao-Hong, Ramos, Eliana Marisa, El-Zein, Karla, Zhao, Yining, Deverasetty, Sandeep, Tebbe, Andreas, Schaab, Christoph, Lavery, Daniel J., Howland, David, Kwak, Seung, Botas, Juan, Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Publicado en Nat Neurosci (2016)

DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

por Lu, Ake T., Narayan, Pritika, Grant, Matthew J., Langfelder, Peter, Wang, Nan, Kwak, Seung, Wilkinson, Hilary, Chen, Richard Z., Chen, Jian, Simon Bawden, C., Rudiger, Skye R., Ciosi, Marc, Chatzi, Afroditi, Maxwell, Alastair, Hore, Timothy A., Aaronson, Jeff, Rosinski, Jim, Preiss, Alicia, Vogt, Thomas F., Coppola, Giovanni, Monckton, Darren, Snell, Russell G., William Yang, X., Horvath, Steve
Publicado en Nat Commun (2020)

Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice

por Bondulich, Marie K., Jolinon, Nelly, Osborne, Georgina F., Smith, Edward J., Rattray, Ivan, Neueder, Andreas, Sathasivam, Kirupa, Ahmed, Mhoriam, Ali, Nadira, Benjamin, Agnesska C., Chang, Xiaoli, Dick, James R. T., Ellis, Matthew, Franklin, Sophie A., Goodwin, Daniel, Inuabasi, Linda, Lazell, Hayley, Lehar, Adam, Richard-Londt, Angela, Rosinski, Jim, Smith, Donna L., Wood, Tobias, Tabrizi, Sarah J., Brandner, Sebastian, Greensmith, Linda, Howland, David, Munoz-Sanjuan, Ignacio, Lee, Se-Jin, Bates, Gillian P.
Publicado en Sci Rep (2017)