Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington’s disease mice

por Mégret, Lucile, Nair, Satish Sasidharan, Dancourt, Julia, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado en BMC Bioinformatics (2020)

Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington’s disease mice synchronous to symptoms

por Bigan, Erwan, Sasidharan Nair, Satish, Lejeune, François-Xavier, Fragnaud, Hélissande, Parmentier, Frédéric, Mégret, Lucile, Verny, Marc, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado en Bioinformatics (2020)

Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

por Megret, Lucile, Gris, Barbara, Sasidharan Nair, Satish, Cevost, Jasmin, Wertz, Mary, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Wilkinson, Hilary, Heiman, Myriam, Neri, Christian
Publicado en eLife (2021)

Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

por Zhang, Yao, Bartz, René, Grigoryan, Gevorg, Bryant, Michael, Aaronson, Jeff, Beck, Stephen, Innocent, Nathalie, Klein, Lee, Procopio, William, Tucker, Tom, Jadhav, Vasant, Tellers, David M., DeGrado, William F.
Publicado en ACS Chem Biol (2015)

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

por Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F., Eszes, Marika, Faull, Richard L.M., Curtis, Maurice A., Waldvogel, Henry J., Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V., Coppola, Giovanni, Yang, X. William
Publicado en Aging (Albany NY) (2016)

DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

por Lu, Ake T., Narayan, Pritika, Grant, Matthew J., Langfelder, Peter, Wang, Nan, Kwak, Seung, Wilkinson, Hilary, Chen, Richard Z., Chen, Jian, Simon Bawden, C., Rudiger, Skye R., Ciosi, Marc, Chatzi, Afroditi, Maxwell, Alastair, Hore, Timothy A., Aaronson, Jeff, Rosinski, Jim, Preiss, Alicia, Vogt, Thomas F., Coppola, Giovanni, Monckton, Darren, Snell, Russell G., William Yang, X., Horvath, Steve
Publicado en Nat Commun (2020)