Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed to striatal degeneration induced by the loss of cortically supplied brain-derived neurotrophic factor (BDNF). Here we show that in mouse mode...

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Detaylı Bibliyografya
Asıl Yazarlar: Plotkin, Joshua L., Day, Michelle, Peterson, Jayms D., Xie, Zhong, Kress, Geraldine J., Rafalovich, Igor, Kondapalli, Jyothisri, Gertler, Tracy S., Flajolet, Marc, Greengard, Paul, Stavarache, Mihaela, Kaplitt, Michael G., Rosinski, Jim, Chan, C. Savio, Surmeier, D. James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131293/
https://ncbi.nlm.nih.gov/pubmed/24991961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.05.032
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