Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed to striatal degeneration induced by the loss of cortically supplied brain-derived neurotrophic factor (BDNF). Here we show that in mouse mode...

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Detalhes bibliográficos
Main Authors: Plotkin, Joshua L., Day, Michelle, Peterson, Jayms D., Xie, Zhong, Kress, Geraldine J., Rafalovich, Igor, Kondapalli, Jyothisri, Gertler, Tracy S., Flajolet, Marc, Greengard, Paul, Stavarache, Mihaela, Kaplitt, Michael G., Rosinski, Jim, Chan, C. Savio, Surmeier, D. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131293/
https://ncbi.nlm.nih.gov/pubmed/24991961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.05.032
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