A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease

Huntington’s disease (HD) is a devastating, genetic neurodegenerative disease caused by a tri-nucleotide expansion in exon 1 of the huntingtin gene. HD is clinically characterized by chorea, emotional and psychiatric disturbances and cognitive deficits with later symptoms including rigidity and deme...

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Main Authors: Todd, Daniel, Gowers, Ian, Dowler, Simon J., Wall, Michael D., McAllister, George, Fischer, David F., Dijkstra, Sipke, Fratantoni, Silvina A., van de Bospoort, Rhea, Veenman-Koepke, Jessica, Flynn, Geraldine, Arjomand, Jamshid, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Wityak, John, Bard, Jonathan A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913682/
https://ncbi.nlm.nih.gov/pubmed/24503862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087923
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