Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed to striatal degeneration induced by the loss of cortically supplied brain-derived neurotrophic factor (BDNF). Here we show that in mouse mode...

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Библиографические подробности
Главные авторы: Plotkin, Joshua L., Day, Michelle, Peterson, Jayms D., Xie, Zhong, Kress, Geraldine J., Rafalovich, Igor, Kondapalli, Jyothisri, Gertler, Tracy S., Flajolet, Marc, Greengard, Paul, Stavarache, Mihaela, Kaplitt, Michael G., Rosinski, Jim, Chan, C. Savio, Surmeier, D. James
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131293/
https://ncbi.nlm.nih.gov/pubmed/24991961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.05.032
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