A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach

Accumulation of α-Synuclein (α-Syn) causes Parkinson's disease (PD) as well as other synucleopathies. α-Syn is the major component of Lewy bodies and Lewy neurites, the proteinaceous aggregates that are a hallmark of sporadic PD. In familial forms of PD, mutations or copy number variations in S...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Rousseaux, Maxime W.C., Vázquez-Vélez, Gabriel E., Al-Ramahi, Ismael, Jeong, Hyun-Hwan, Bajić, Aleksandar, Revelli, Jean-Pierre, Ye, Hui, Phan, Emily T., Deger, Jennifer M., Perez, Alma M., Kim, Ji-Yoen, Lavery, Laura A., Xu, Qikia, Li, Mamie Z., Kang, Hyojin, Kim, Jean J., Shulman, Joshua M., Westbrook, Thomas F., Elledge, Stephen J., Liu, Zhandong, Botas, Juan, Zoghbi, Huda Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199406/
https://ncbi.nlm.nih.gov/pubmed/30249792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0254-18.2018
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