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Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau
Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the levels and toxicity of α-Syn and tau (Rou...
Kaydedildi:
| Yayımlandı: | eLife |
|---|---|
| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications, Ltd
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5993537/ https://ncbi.nlm.nih.gov/pubmed/29863470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36768 |
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