Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau

Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the levels and toxicity of α-Syn and tau (Rou...

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Bibliographic Details
Published in:eLife
Main Authors: Rousseaux, Maxime WC, Revelli, Jean-Pierre, Vázquez-Vélez, Gabriel E, Kim, Ji-Yoen, Craigen, Evelyn, Gonzales, Kristyn, Beckinghausen, Jaclyn, Zoghbi, Huda Y
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993537/
https://ncbi.nlm.nih.gov/pubmed/29863470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36768
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