Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

por Seiler, Michael, Peng, Shouyong, Agrawal, Anant A., Palacino, James, Teng, Teng, Zhu, Ping, Smith, Peter G., Buonamici, Silvia, Yu, Lihua
Publicado en Cell Rep (2018)

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

por Yao, Yuwei, Cui, Xiaotian, Al-Ramahi, Ismael, Sun, Xiaoli, Li, Bo, Hou, Jiapeng, Difiglia, Marian, Palacino, James, Wu, Zhi-Ying, Ma, Lixiang, Botas, Juan, Lu, Boxun
Publicado en eLife (2015)

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

por Kegel, Kimberly B, Sapp, Ellen, Alexander, Jonathan, Reeves, Patrick, Bleckmann, Dorothee, Sobin, Linsday, Masso, Nicholas, Valencia, Antonio, Jeong, Hyunkyung, Krainc, Dimitri, Palacino, James, Curtis, Daniel, Kuhn, Rainer, Betschart, Claudia, Sena-Esteves, Miguel, Aronin, Neil, Paganetti, Paolo, DiFiglia, Marian
Publicado 2010

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

por Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Zhenhua Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter G., Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping
Publicado en Nat Commun (2019)

High-throughput functional analysis distinguishes pathogenic, nonpathogenic, and compensatory transcriptional changes in a neurodegenerative disorder

por Al-Ramahi, Ismael, Lu, Boxun, Di Paola, Simone, Pang, Kaifang, de Haro, Maria, Peluso, Ivana, Gallego-Flores, Tatiana, Malik, Nazish T., Erikson, Kelly, Bleiberg, Benjamin A., Avalos, Matthew, Fan, George, Rivers, Laura Elizabeth, Laitman, Andrew M., Diaz-García, Javier R., Hild, Marc, Palacino, James, Liu, Zhandong, Medina, Diego L., Botas, Juan
Publicado en Cell Syst (2018)

Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations

por Lee, Stanley Chun-Wei, Dvinge, Heidi, Kim, Eunhee, Cho, Hana, Micol, Jean-Baptiste, Chung, Young Rock, Durham, Benjamin H., Yoshimi, Akihide, Kim, Young Joon, Thomas, Michael, Lobry, Camille, Chen, Chun-Wei, Pastore, Alessandro, Taylor, Justin, Wang, Xujun, Krivtsov, Andrei, Armstrong, Scott A., Palacino, James, Buonamici, Silvia, Smith, Peter G., Bradley, Robert K., Abdel-Wahab, Omar
Publicado en Nat Med (2016)

Corrigendum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

por Lee, Stanley Chun-Wei, Dvinge, Heidi, Kim, Eunhee, Cho, Hana, Micol, Jean-Baptiste, Chung, Young Rock, Durham, Benjamin H, Yoshimi, Akihide, Kim, Young Joon, Thomas, Michael, Lobry, Camille, Chen, Chun-Wei, Pastore, Alessandro, Taylor, Justin, Wang, Xujun, Krivtsov, Andrei, Armstrong, Scott A, Palacino, James, Buonamici, Silvia, Smith, Peter G, Bradley, Robert K, Abdel-Wahab, Omar
Publicado en Nat Med (2016)

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

por Teng, Teng, Tsai, Jennifer HC, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Prajapati, Sudeep, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Gerard, Baudouin, Karr, Craig, Korpal, Manav, Liu, Xiang, T. Lowe, Jason, Mizui, Yoshiharu, Palacino, James, Park, Eunice, Smith, Peter G., Subramanian, Vanitha, Wu, Zhenhua Jeremy, Zou, Jian, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping
Publicado en Nat Commun (2017)

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

por Lee, Stanley Chun-Wei, North, Khrystyna, Kim, Eunhee, Jang, Eunjung, Obeng, Esther, Lu, Sydney X., Liu, Bo, Inoue, Daichi, Yoshimi, Akihide, Ki, Michelle, Yeo, Mirae, Zhang, Xiao Jing, Kim, Min Kyung, Cho, Hana, Chung, Young Rock, Taylor, Justin, Durham, Benjamin H., Kim, Young Joon, Pastore, Alessandro, Monette, Sebastien, Palacino, James, Seiler, Michael, Buonamici, Silvia, Smith, Peter G., Ebert, Benjamin L., Bradley, Robert K., Abdel-Wahab, Omar
Publicado en Cancer Cell (2018)