Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations

Mutations in spliceosomal genes are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)(1–3). These mutations occur at highly recurrent amino acid residues and perturb normal splice site and exon recognition(4–6). Spliceosomal mutations are always heteroz...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Med
Egile Nagusiak: Lee, Stanley Chun-Wei, Dvinge, Heidi, Kim, Eunhee, Cho, Hana, Micol, Jean-Baptiste, Chung, Young Rock, Durham, Benjamin H., Yoshimi, Akihide, Kim, Young Joon, Thomas, Michael, Lobry, Camille, Chen, Chun-Wei, Pastore, Alessandro, Taylor, Justin, Wang, Xujun, Krivtsov, Andrei, Armstrong, Scott A., Palacino, James, Buonamici, Silvia, Smith, Peter G., Bradley, Robert K., Abdel-Wahab, Omar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899191/
https://ncbi.nlm.nih.gov/pubmed/27135740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4097
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