Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations

Mutations in spliceosomal genes are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)(1–3). These mutations occur at highly recurrent amino acid residues and perturb normal splice site and exon recognition(4–6). Spliceosomal mutations are always heteroz...

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Udgivet i:Nat Med
Main Authors: Lee, Stanley Chun-Wei, Dvinge, Heidi, Kim, Eunhee, Cho, Hana, Micol, Jean-Baptiste, Chung, Young Rock, Durham, Benjamin H., Yoshimi, Akihide, Kim, Young Joon, Thomas, Michael, Lobry, Camille, Chen, Chun-Wei, Pastore, Alessandro, Taylor, Justin, Wang, Xujun, Krivtsov, Andrei, Armstrong, Scott A., Palacino, James, Buonamici, Silvia, Smith, Peter G., Bradley, Robert K., Abdel-Wahab, Omar
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899191/
https://ncbi.nlm.nih.gov/pubmed/27135740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4097
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