Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations

Mutations in spliceosomal genes are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)(1–3). These mutations occur at highly recurrent amino acid residues and perturb normal splice site and exon recognition(4–6). Spliceosomal mutations are always heteroz...

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Publicado no:Nat Med
Main Authors: Lee, Stanley Chun-Wei, Dvinge, Heidi, Kim, Eunhee, Cho, Hana, Micol, Jean-Baptiste, Chung, Young Rock, Durham, Benjamin H., Yoshimi, Akihide, Kim, Young Joon, Thomas, Michael, Lobry, Camille, Chen, Chun-Wei, Pastore, Alessandro, Taylor, Justin, Wang, Xujun, Krivtsov, Andrei, Armstrong, Scott A., Palacino, James, Buonamici, Silvia, Smith, Peter G., Bradley, Robert K., Abdel-Wahab, Omar
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899191/
https://ncbi.nlm.nih.gov/pubmed/27135740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4097
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