Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 co...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Teng, Teng, Tsai, Jennifer HC, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Prajapati, Sudeep, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Gerard, Baudouin, Karr, Craig, Korpal, Manav, Liu, Xiang, T. Lowe, Jason, Mizui, Yoshiharu, Palacino, James, Park, Eunice, Smith, Peter G., Subramanian, Vanitha, Wu, Zhenhua Jeremy, Zou, Jian, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458519/
https://ncbi.nlm.nih.gov/pubmed/28541300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15522
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller