Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model

Many neurodegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disease-related proteins. As growing evidence indicates that reducing the steady-state levels of disease-causing proteins mitigates neurodegeneration in animal models, we developed a strategy to...

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Publicat a:Neuron
Autors principals: Lasagna-Reeves, Cristian A., de Haro, Maria, Hao, Shuang, Park, Jeehye, Rousseaux, Maxime W.C., Al-Ramahi, Ismael, Jafar-Nejad, Paymaan, Vilanova-Velez, Luis, See, Lauren, De Maio, Antonia, Nitschke, Larissa, Wu, Zhenyu, Troncoso, Juan C., Westbrook, Thomas F., Tang, Jianrong, Botas, Juan, Zoghbi, Huda.Y.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745060/
https://ncbi.nlm.nih.gov/pubmed/27720485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.09.022
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