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Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by expansion of a glutamine-encoding repeat in SCA1. In all known polyglutamine diseases, the glutamine expansion confers toxic functions onto the protein. The mechanism by which this occurs remains enigm...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2377396/ https://ncbi.nlm.nih.gov/pubmed/18337722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06731 |
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