A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

Recent studies indicate that soluble oligomers drive pathogenesis in several neurodegenerative proteinopathies, including Alzheimer and Parkinson disease. Curiously, the same conformational antibody recognizes different disease-related oligomers, despite the variations in clinical presentation and b...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Lasagna-Reeves, Cristian A, Rousseaux, Maxime WC, Guerrero-Muñoz, Marcos J, Park, Jeehye, Jafar-Nejad, Paymaan, Richman, Ronald, Lu, Nan, Sengupta, Urmi, Litvinchuk, Alexandra, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2015
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462648/
https://ncbi.nlm.nih.gov/pubmed/25988806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07558
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