Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1 Transgenic Mice

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant, polyglutamine-induced neurodegenerative disorder that results in loss of motor coordination caused primarily by a disruption of cerebellar Purkinje cell function. In this study, we developed a conditional SCA1 mouse model to examine whet...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zu, Tao, Duvick, Lisa A., Kaytor, Michael D., Berlinger, Michael S., Zoghbi, Huda Y., Clark, H. Brent, Orr, Harry T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729947/
https://ncbi.nlm.nih.gov/pubmed/15470152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2978-04.2004
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