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Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model

Spinocerebellar ataxia type 1 (SCA1) is one of nine dominantly inherited neurodegenerative diseases caused by polyglutamine tract expansion. In SCA1, the expanded polyglutamine tract is in the ataxin-1 (ATXN1) protein. ATXN1 is part of an in vivo complex with retinoid acid receptor-related orphan re...

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Detalhes bibliográficos
Main Authors: Gehrking, Kristin M., Andresen, J. Michael, Duvick, Lisa, Lough, John, Zoghbi, Huda Y., Orr, Harry T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090197/
https://ncbi.nlm.nih.gov/pubmed/21427130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr108
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