dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1

Spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of neurodegenerative disorders sharing atrophy of the cerebellum as a common feature. SCA1 and SCA2 are two ataxias caused by expansion of polyglutamine tracts in Ataxin-1 (ATXN1) and Ataxin-2 (ATXN2), respectively, two proteins th...

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Autors principals: Al-Ramahi, Ismael, Pérez, Alma M, Lim, Janghoo, Zhang, Minghang, Sorensen, Rie, de Haro, Maria, Branco, Joana, Pulst, Stefan M, Zoghbi, Huda Y, Botas, Juan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323314/
https://ncbi.nlm.nih.gov/pubmed/18166084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030234
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