Tat-DJ-1 inhibits oxidative stress-mediated RINm5F cell death through suppression of NF-κB and MAPK activation

Por Jo, Hyo Sang, Cha, Hyun Ju, Kim, Sang Jin, Yeo, Hyeon Ji, Cho, Su Bin, Park, Jung Hwan, Lee, Chi Hern, Yeo, Eun Ji, Choi, Yeon Joo, Eum, Won Sik, Choi, Soo Young
Publicado no Med Chem Res (2016)

Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles

Por Kuo, Cheng-Hsiang, Leon, Lorraine, Chung, Eun Ji, Huang, Ru-Ting, Sontag, Timothy J., Reardon, Catherine A., Getz, Godfrey S., Tirrell, Matthew, Fang, Yun
Publicado no J Mater Chem B Mater Biol Med (2014)

Corrigendum to “Synthesis and cytotoxic activity of novel Aring cleaved ursolic acid derivatives in human nonsmall cell lung cancer cells” [Eur. J. Med. Chem. 123 (2016) 317–331]

Por Mendes, Vanessa I. S., Bartholomeusz, Geoffrey A., Ayres, Mary, Gandhi, Varsha, Salvador, Jorge A. R.
Publicado no Eur J Med Chem (2016)

Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells

Por Garcia, Francisco J., Carroll, Kate S.
Publicado no Eur J Med Chem (2014)

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

Por Ghizzoni, Massimo, Wu, Jiang, Gao, Tielong, Haisma, Hidde J., Dekker, Frank J., Zheng, Y. George
Publicado em 2011

A Molecular Model for Cocaine Binding by the Immunotherapeutic Human/Mouse Chimeric Monoclonal Antibody 2E2

Por Lape, Michael, Paula, Stefan, Ball, William J.
Publicado em 2010

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Por Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado no Eur J Med Chem (2016)

Design of a novel Thiophene Inhibitor of 15-Lipoxygenase-1 with both Anti-inflammatory and Neuroprotective Properties

Por Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G. J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.
Publicado no Eur J Med Chem (2016)

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

Por Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Publicado no Eur J Med Chem (2016)

Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors

Por Huang, Wenlin, Zhang, Zhongsheng, Barros-Álvarez, Ximena, Koh, Cho Yeow, Ranade, Ranae M., Gillespie, J. Robert, Creason, Sharon A., Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no Eur J Med Chem (2016)

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

Por Hoeger, Birgit, Diether, Maren, Ballester, Pedro J., Köhn, Maja
Publicado no Eur J Med Chem (2014)

Synthesis and pharmacological evaluation of indole-based sigma receptor ligands

Por Mésangeau, Christophe, Amata, Emanuele, Alsharif, Walid, Seminerio, Michael J., Robson, Matthew J., Matsumoto, Rae R., Poupaert, Jacques H., McCurdy, Christopher R.
Publicado em 2011

The relevance of K(i) calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor

Por Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G. J., van der Wouden, Petra E., Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.
Publicado no Eur J Med Chem (2017)

Synthesis and Biological Evaluation of Novel Hybrids of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists

Por Zhang, Han-Kun, Eaton, J. Brek, Fedolak, Allison, Gunosewoyo, Hendra, Onajole, Oluseye K., Brunner, Dani, Lukas, Ronald J., Yu, Li-Fang, Kozikowski, Alan P.
Publicado no Eur J Med Chem (2016)

Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors

Por Binder, Randall J., Hatfield, M. Jason, Chi, Liying, Potter, Philip M.
Publicado no Eur J Med Chem (2018)

Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor

Por Grieco, Paolo, Brancaccio, Diego, Novellino, Ettore, Hruby, Victor J., Carotenuto, Alfonso
Publicado no Eur J Med Chem (2011)

Synthesis and Biological Evaluation of Isomeric Methoxy Substitutions on Anti-Cancer Indolyl-Pyridinyl-Propenones: Effects on Potency and Mode of Activity

Por Trabbic, Christopher J., George, Sage M., Alexander, Evan M., Du, Shengnan, Offenbacher, Jennifer M., Crissman, Emily J., Overmeyer, Jean H., Maltese, William A., Erhardt, Paul W.
Publicado no Eur J Med Chem (2016)

E-2-[3-(3,4-Dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1,4-dioxide: A lead antitubercular agent which alters mitochondrial respiration in rat liver

Por Das, Umashankar, Das, Swagatika, Bandy, Brian, Gorecki, Dennis K.J., Dimmock, Jonathan R.
Publicado em 2010

N(1),N(1)-dimethyl-N(3)-(3-(trifluoromethyl)phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis

Por Pham, Ngoc B., Deydier, Sophie, Labaied, Mehdi, Monnerat, Séverine, Stuart, Kenneth, Quinn, Ronald J.
Publicado no Eur J Med Chem (2014)

Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes

Por Kelley, Cody, Lu, Songfeng, Parhi, Ajit, Kaul, Malvika, Pilch, Daniel S., LaVoie, Edmond J.
Publicado em 2012