2-(3-Fluoro-4-methylsulfonylaminophenyl) Propanamides as Potent Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists: Structure Activity Relationships of 2-Amino Derivative...

Por Kim, Myeong Seop, Ryu, HyungChul, Kang, Dong Wook, Cho, Seong-Hee, Seo, Sejin, Park, Young Soo, Kim, Mi-Yeon, Kwak, Eun Joo, Kim, Yong Soo, Bhondwe, Rahul S., Kim, Ho Shin, Park, Seul-gi, Son, Karam, Choi, Sun, DeAndrea-Lazarus, Ian, Pearce, Larry V., Blumberg, Peter M., Frank, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Kögel, Babette Y., Schiene, Klaus, Christoph, Thomas, Lee, Jeewoo
Publicado em 2012

Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles

Por Kuo, Cheng-Hsiang, Leon, Lorraine, Chung, Eun Ji, Huang, Ru-Ting, Sontag, Timothy J., Reardon, Catherine A., Getz, Godfrey S., Tirrell, Matthew, Fang, Yun
Publicado no J Mater Chem B Mater Biol Med (2014)

Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells

Por Garcia, Francisco J., Carroll, Kate S.
Publicado no Eur J Med Chem (2014)

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

Por Ghizzoni, Massimo, Wu, Jiang, Gao, Tielong, Haisma, Hidde J., Dekker, Frank J., Zheng, Y. George
Publicado em 2011

A Molecular Model for Cocaine Binding by the Immunotherapeutic Human/Mouse Chimeric Monoclonal Antibody 2E2

Por Lape, Michael, Paula, Stefan, Ball, William J.
Publicado em 2010

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Por Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado no Eur J Med Chem (2016)

Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics

Por Trunkfield, Amy E., Gurcha, Sudagar S., Besra, Gurdyal S., Bugg, Timothy D.H.
Publicado em 2010

Design of a novel Thiophene Inhibitor of 15-Lipoxygenase-1 with both Anti-inflammatory and Neuroprotective Properties

Por Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G. J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.
Publicado no Eur J Med Chem (2016)

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

Por Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Publicado no Eur J Med Chem (2016)

Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors

Por Huang, Wenlin, Zhang, Zhongsheng, Barros-Álvarez, Ximena, Koh, Cho Yeow, Ranade, Ranae M., Gillespie, J. Robert, Creason, Sharon A., Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no Eur J Med Chem (2016)

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

Por Hoeger, Birgit, Diether, Maren, Ballester, Pedro J., Köhn, Maja
Publicado no Eur J Med Chem (2014)

Synthesis and pharmacological evaluation of indole-based sigma receptor ligands

Por Mésangeau, Christophe, Amata, Emanuele, Alsharif, Walid, Seminerio, Michael J., Robson, Matthew J., Matsumoto, Rae R., Poupaert, Jacques H., McCurdy, Christopher R.
Publicado em 2011

Synthesis and Biological Evaluation of Novel Hybrids of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists

Por Zhang, Han-Kun, Eaton, J. Brek, Fedolak, Allison, Gunosewoyo, Hendra, Onajole, Oluseye K., Brunner, Dani, Lukas, Ronald J., Yu, Li-Fang, Kozikowski, Alan P.
Publicado no Eur J Med Chem (2016)

Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor

Por Grieco, Paolo, Brancaccio, Diego, Novellino, Ettore, Hruby, Victor J., Carotenuto, Alfonso
Publicado no Eur J Med Chem (2011)

Synthesis and Biological Evaluation of Isomeric Methoxy Substitutions on Anti-Cancer Indolyl-Pyridinyl-Propenones: Effects on Potency and Mode of Activity

Por Trabbic, Christopher J., George, Sage M., Alexander, Evan M., Du, Shengnan, Offenbacher, Jennifer M., Crissman, Emily J., Overmeyer, Jean H., Maltese, William A., Erhardt, Paul W.
Publicado no Eur J Med Chem (2016)

E-2-[3-(3,4-Dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1,4-dioxide: A lead antitubercular agent which alters mitochondrial respiration in rat liver

Por Das, Umashankar, Das, Swagatika, Bandy, Brian, Gorecki, Dennis K.J., Dimmock, Jonathan R.
Publicado em 2010

N(1),N(1)-dimethyl-N(3)-(3-(trifluoromethyl)phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis

Por Pham, Ngoc B., Deydier, Sophie, Labaied, Mehdi, Monnerat, Séverine, Stuart, Kenneth, Quinn, Ronald J.
Publicado no Eur J Med Chem (2014)

Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes

Por Kelley, Cody, Lu, Songfeng, Parhi, Ajit, Kaul, Malvika, Pilch, Daniel S., LaVoie, Edmond J.
Publicado em 2012

Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs

Por Chitneni, Satish K., Reitman, Zachary J., Gooden, David M., Yan, Hai, Zalutsky, Michael R.
Publicado no Eur J Med Chem (2016)

Phenethyl pyridines with non-polar internal substitutents as selective ligands for estrogen receptor beta

Por Waibel, Michael, Kieser, Karen J., Carlson, Kathryn E., Stossi, Fabio, Katzenellenbogen, Benita S., Katzenellenbogen, John A.
Publicado em 2009