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Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics

Glycosyltransferase MurG catalyses the transfer of N-acetyl-d-glucosamine to lipid intermediate I on the bacterial peptidoglycan biosynthesis pathway, and is a target for development of new antibacterial agents. A transition state mimic was designed for MurG, containing a functionalised proline, lin...

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Autors principals: Trunkfield, Amy E., Gurcha, Sudagar S., Besra, Gurdyal S., Bugg, Timothy D.H.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034214/
https://ncbi.nlm.nih.gov/pubmed/20226679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.026
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