Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives

door Nelson, Shawn D., Wawer, Mathias J., Schreiber, Stuart L.
Gepubliceerd in Org Lett (2016)

DNA barcoding a complete matrix of stereoisomeric small molecules

door Gerry, Christopher J., Wawer, Mathias J., Clemons, Paul A., Schreiber, Stuart L.
Gepubliceerd in J Am Chem Soc (2019)

Automated structure–activity relationship mining: connecting chemical structure to biological profiles

door Wawer, Mathias J., Jaramillo, David E., Dancik, Vlado, Fass, Daniel M., Haggarty, Stephen J., Shamji, Alykhan F., Wagner, Bridget K., Schreiber, Stuart L., Clemons, Paul A.
Gepubliceerd in J Biomol Screen (2014)

Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds

door Melillo, Bruno, Zoller, Jochen, Hua, Bruce K., Verho, Oscar, Borghs, Jannik C., Nelson, Shawn D., Maetani, Micah, Wawer, Mathias J., Clemons, Paul A., Schreiber, Stuart L.
Gepubliceerd in J Am Chem Soc (2018)

Real-Time Biological Annotation of Synthetic Compounds

door Gerry, Christopher J., Hua, Bruce K., Wawer, Mathias J., Knowles, Jonathan P., Nelson Jr., Shawn D., Verho, Oscar, Dandapani, Sivaraman, Wagner, Bridget K., Clemons, Paul A., Booker-Milburn, Kevin I., Boskovic, Zarko V., Schreiber, Stuart L.
Gepubliceerd in J Am Chem Soc (2016)

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

door Sheppard, Hadley E., Dall’Agnese, Alessandra, Park, Woojun D., Shamim, M. Hamza, Dubrulle, Julien, Johnson, Hannah L., Stossi, Fabio, Cogswell, Patricia, Sommer, Josh, Levy, Joan, Sharifnia, Tanaz, Wawer, Mathias J., Nabet, Behnam, Gray, Nathanael S., Clemons, Paul A., Schreiber, Stuart L., Workman, Paul, Young, Richard A., Lin, Charles Y.
Gepubliceerd in Cell Rep Med (2021)

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

door Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E
Gepubliceerd in Gigascience (2017)

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

door Viswanathan, Srinivas R., Nogueira, Marina F., Buss, Colin G., Krill-Burger, John M., Wawer, Mathias J., Malolepsza, Edyta, Berger, Ashton C., Choi, Peter S., Shih, Juliann, Taylor, Alison M., Tanenbaum, Benjamin, Pedamallu, Chandra Sekhar, Cherniack, Andrew D., Tamayo, Pablo, Strathdee, Craig A., Lage, Kasper, Carr, Steven A., Schenone, Monica, Bhatia, Sangeeta N., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Meyerson, Matthew
Gepubliceerd in Nat Genet (2018)

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

door Wawer, Mathias J., Li, Kejie, Gustafsdottir, Sigrun M., Ljosa, Vebjorn, Bodycombe, Nicole E., Marton, Melissa A., Sokolnicki, Katherine L., Bray, Mark-Anthony, Kemp, Melissa M., Winchester, Ellen, Taylor, Bradley, Grant, George B., Hon, C. Suk-Yee, Duvall, Jeremy R., Wilson, J. Anthony, Bittker, Joshua A., Dančík, Vlado, Narayan, Rajiv, Subramanian, Aravind, Winckler, Wendy, Golub, Todd R., Carpenter, Anne E., Shamji, Alykhan F., Schreiber, Stuart L., Clemons, Paul A.
Gepubliceerd in 2014

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

door Seashore-Ludlow, Brinton, Rees, Matthew G., Cheah, Jaime H., Cokol, Murat, Price, Edmund V., Coletti, Matthew E., Jones, Victor, Bodycombe, Nicole E., Soule, Christian K., Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J., Kuru, Nurdan, Kotz, Joanne D., Hon, C. Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A., Palmer, Michelle, Bradner, James E., Shamji, Alykhan F., Clemons, Paul A., Schreiber, Stuart L.
Gepubliceerd in Cancer Discov (2015)

Small-molecule targeting of brachyury transcription factor addiction in chordoma

door Sharifnia, Tanaz, Wawer, Mathias J., Chen, Ting, Huang, Qing-Yuan, Weir, Barbara A., Sizemore, Ann, Lawlor, Matthew A., Goodale, Amy, Cowley, Glenn S., Vazquez, Francisca, Ott, Christopher J., Francis, Joshua M., Sassi, Slim, Cogswell, Patricia, Sheppard, Hadley E., Zhang, Tinghu, Gray, Nathanael S., Clarke, Paul A., Blagg, Julian, Workman, Paul, Sommer, Josh, Hornicek, Francis, Root, David E., Hahn, William C., Bradner, James E., Wong, Kwok K., Clemons, Paul A., Lin, Charles Y., Kotz, Joanne D., Schreiber, Stuart L.
Gepubliceerd in Nat Med (2019)

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

door Sykes, David B., Kfoury, Youmna S., Mercier, François E., Wawer, Mathias J., Law, Jason M., Haynes, Mark K., Lewis, Timothy A., Schajnovitz, Amir, Jain, Esha, Lee, Dongjun, Meyer, Hanna, Pierce, Kerry A., Tolliday, Nicola J., Waller, Anna, Ferrara, Steven J., Eheim, Ashley L., Stoeckigt, Detlef, Maxcy, Katrina L., Cobert, Julien M., Bachand, Jacqueline, Szekely, Brian A., Mukherjee, Siddhartha, Sklar, Larry A., Kotz, Joanne D., Clish, Clary B., Sadreyev, Ruslan I., Clemons, Paul A., Janzer, Andreas, Schreiber, Stuart L., Scadden, David T.
Gepubliceerd in Cell (2016)

Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes

door Schreiber, Stuart L., Kotz, Joanne D., Li, Min, Aubé, Jeffrey, Austin, Christopher P., Reed, John C., Rosen, Hugh, White, E. Lucile, Sklar, Larry A., Lindsley, Craig W., Alexander, Benjamin R., Bittker, Joshua A., Clemons, Paul A., de Souza, Andrea, Foley, Michael A., Palmer, Michelle, Shamji, Alykhan F., Wawer, Mathias J., McManus, Owen, Wu, Meng, Zou, Beiyan, Yu, Haibo, Golden, Jennifer E., Schoenen, Frank J., Simeonov, Anton, Jadhav, Ajit, Jackson, Michael R., Pinkerton, Anthony B., Chung, Thomas D.Y., Griffin, Patrick R., Cravatt, Benjamin F., Hodder, Peter S., Roush, William R., Roberts, Edward, Chung, Dong-Hoon, Jonsson, Colleen B., Noah, James W., Severson, William E., Ananthan, Subramaniam, Edwards, Bruce, Oprea, Tudor I., Conn, P. Jeffrey, Hopkins, Corey R., Wood, Michael R., Stauffer, Shaun R., Emmitte, Kyle A.
Gepubliceerd in Cell (2015)

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

door Kato, Nobutaka, Comer, Eamon, Sakata-Kato, Tomoyo, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M., Bittker, Joshua A., Corey, Victoria, Clarke, David, Derbyshire, Emily R., Dornan, Gillian L., Duffy, Sandra, Eckley, Sean, Itoe, Maurice A., Koolen, Karin M. J., Lewis, Timothy A., Lui, Ping S., Lukens, Amanda K., Lund, Emily, March, Sandra, Meibalan, Elamaran, Meier, Bennett C., McPhail, Jacob A., Mitasev, Branko, Moss, Eli L., Sayes, Morgane, Van Gessel, Yvonne, Wawer, Mathias J., Yoshinaga, Takashi, Zeeman, Anne-Marie, Avery, Vicky M., Bhatia, Sangeeta N., Burke, John E., Catteruccia, Flaminia, Clardy, Jon C., Clemons, Paul A., Dechering, Koen J., Duvall, Jeremy R., Foley, Michael A., Gusovsky, Fabian, Kocken, Clemens H. M., Marti, Matthias, Morningstar, Marshall L., Munoz, Benito, Neafsey, Daniel E., Sharma, Amit, Winzeler, Elizabeth A., Wirth, Dyann F., Scherer, Christina A., Schreiber, Stuart L.
Gepubliceerd in Nature (2016)