Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

High-throughput screening has become a mainstay of small-molecule probe and early drug discovery. The question of how to build and evolve efficient screening collections systematically for cell-based and biochemical screening is still unresolved. It is often assumed that chemical structure diversity...

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Bibliografski detalji
Glavni autori: Wawer, Mathias J., Li, Kejie, Gustafsdottir, Sigrun M., Ljosa, Vebjorn, Bodycombe, Nicole E., Marton, Melissa A., Sokolnicki, Katherine L., Bray, Mark-Anthony, Kemp, Melissa M., Winchester, Ellen, Taylor, Bradley, Grant, George B., Hon, C. Suk-Yee, Duvall, Jeremy R., Wilson, J. Anthony, Bittker, Joshua A., Dančík, Vlado, Narayan, Rajiv, Subramanian, Aravind, Winckler, Wendy, Golub, Todd R., Carpenter, Anne E., Shamji, Alykhan F., Schreiber, Stuart L., Clemons, Paul A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Physical Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121832/
https://ncbi.nlm.nih.gov/pubmed/25024206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410933111
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