Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells

par Vangamudi, Bhavatarini, Zhu, Shoumin, Soutto, Mohammed, Belkhiri, Abbes, El-Rifai, Wael
Publié 2011

t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer

par Vangamudi, Bhavatarini, Peng, Dun-Fa, Cai, Qiuyin, El-Rifai, Wael, Zheng, Wei, Belkhiri, Abbes
Publié 2010

Surface reengineering of RPA70N enables co-crystallization with an inhibitor of the RPA interaction motif of ATRIP

par Feldkamp, Michael D., Frank, Andreas O., Kennedy, J. Phillip, Patrone, James D., Vangamudi, Bhavatarini, Waterson, Alex G., Fesik, Stephen W., Chazin, Walter J.
Publié 2013

Discovery of Protein–Protein Interaction Inhibitors of Replication Protein A

par Patrone, James D., Kennedy, J. Phillip, Frank, Andreas O., Feldkamp, Michael D., Vangamudi, Bhavatarini, Pelz, Nicholas F., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.
Publié 2013

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

par Frank, Andreas O., Vangamudi, Bhavatarini, Feldkamp, Michael D., Souza-Fagundes, Elaine M., Luzwick, Jessica W., Cortez, David, Olejniczak, Edward T., Waterson, Alex G., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publié 2014

Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions Using a Fragment Linking Approach

par Frank, Andreas O., Feldkamp, Michael D., Kennedy, J. Phillip, Waterson, Alex G., Pelz, Nicholas F., Patrone, James D., Vangamudi, Bhavatarini, Camper, DeMarco V., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publié 2013

Diphenylpyrazoles as Replication Protein A Inhibitors

par Waterson, Alex G., Kennedy, J. Phillip, Patrone, James D., Pelz, Nicholas F., Feldkamp, Michael D., Frank, Andreas O., Vangamudi, Bhavatarini, Souza-Fagundes, Elaine M., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publié dans ACS Med Chem Lett (2014)

Identification and Optimization of Anthranilic Acid-Based Inhibitors of Replication Protein A

par Patrone, James D., Pelz, Nicholas F., Bates, Brittney S., Souza-Fagundes, Elaine M., Vangamudi, Bhavatarini, Camper, Demarco V., Kuznetsov, Alexey G., Browning, Carrie F., Feldkamp, Michael D., Frank, Andreas O., Gilston, Benjamin A., Olejniczak, Edward T., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.
Publié dans ChemMedChem (2016)

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

par Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P., Shepard, Hannah E., Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N., Jiang, Shiming, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S., Geck Do, Mary K., Andersen, Jannik N.
Publié dans Epigenetics Chromatin (2015)

The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies

par Vangamudi, Bhavatarini, Paul, Thomas A., Shah, Parantu K., Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S., Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N., Peoples, Mike, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R., Draetta, Giulio, Jones, Philip, Palmer, Wylie S., Sharma, Shikhar, Andersen, Jannik N.
Publié dans Cancer Res (2015)

Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs

par Golder, Matthew R., Liu, Jenny, Andersen, Jannik N., Shipitsin, Michail V., Vohidov, Farrukh, Nguyen, Hung V.-T., Ehrlich, Deborah C., Huh, Sung Jin, Vangamudi, Bhavatarini, Economides, Kyriakos D., Neenan, Allison M., Ackley, James C., Baddour, Joelle, Paramasivan, Sattanathan, Brady, Samantha W., Held, Eric J., Reiter, Lawrence A., Saucier-Sawyer, Jennifer K., Kopesky, Paul W., Chickering, Donald E., Blume-Jensen, Peter, Johnson, Jeremiah A.
Publié dans Nat Biomed Eng (2018)

Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities

par Vohidov, Farrukh, Andersen, Jannik N., Economides, Kyriakos D., Shipitsin, Michail V., Burenkova, Olga, Ackley, James C., Vangamudi, Bhavatarini, Nguyen, Hung V.-T., Gallagher, Nolan M., Shieh, Peyton, Golder, Matthew R., Liu, Jenny, Dahlberg, William K., Ehrlich, Deborah J. C., Kim, Julie, Kristufek, Samantha L., Jin Huh, Sung, Neenan, Allison M., Baddour, Joelle, Paramasivan, Sattanathan, de Stanchina, Elisa, Gaurab, KC, Turnquist, David J., Saucier-Sawyer, Jennifer K., Kopesky, Paul W., Brady, Samantha W., Jessel, Michael J., Reiter, Lawrence A., Chickering, Donald E., Johnson, Jeremiah A., Blume-Jensen, Peter
Publié dans J Am Chem Soc (2021)

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

par Giuliani, Virginia, Miller, Meredith A., Liu, Chiu-Yi, Hartono, Stella R., Class, Caleb A., Bristow, Christopher A., Suzuki, Erika, Sanz, Lionel A., Gao, Guang, Gay, Jason P., Feng, Ningping, Rose, Johnathon L., Tomihara, Hideo, Daniele, Joseph R., Peoples, Michael D., Bardenhagen, Jennifer P., Geck Do, Mary K., Chang, Qing E., Vangamudi, Bhavatarini, Vellano, Christopher, Ying, Haoqiang, Deem, Angela K., Do, Kim-Anh, Genovese, Giannicola, Marszalek, Joseph R., Kovacs, Jeffrey J., Kim, Michael, Fleming, Jason B., Guccione, Ernesto, Viale, Andrea, Maitra, Anirban, Emilia Di Francesco, M., Yap, Timothy A., Jones, Philip, Draetta, Giulio, Carugo, Alessandro, Chedin, Frederic, Heffernan, Timothy P.
Publié dans Nat Commun (2021)