Prodrug-activating systems in suicide gene therapy

द्वारा Springer, Caroline J., Niculescu-Duvaz, Ion
प्रकाशित 2000

Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance

द्वारा Jamin, Yann, Eykyn, Thomas R., Poon, Evon, Springer, Caroline J., Robinson, Simon P.
में प्रकाशित Mol Imaging Biol (2014)

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

द्वारा Heidorn, Sonja J., Milagre, Carla, Whittaker, Steven, Nourry, Arnaud, Niculescu-Duvas, Ion, Dhomen, Nathalie, Hussain, Jahan, Reis-Filho, Jorge S., Springer, Caroline J., Pritchard, Catrin, Marais, Richard
प्रकाशित 2010

Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow

द्वारा Brown, Michael, Aljarah, Mohammed, Asiki, Hannah, Leung, Leo M. H., Smithen, Deborah A., Miller, Natalie, Nemeth, Gabor, Davies, Lawrence, Niculescu-Duvaz, Dan, Zambon, Alfonso, Springer, Caroline
में प्रकाशित Org Process Res Dev (2020)

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia

द्वारा Packer, Leisl M., Rana, Sareena, Hayward, Robert, O'Hare, Thomas, Eide, Christopher A., Rebocho, Ana, Heidorn, Sonja, Zabriskie, Matthew S., Niculescu-Duvaz, Ion, Druker, Brian J., Springer, Caroline, Marais, Richard
प्रकाशित 2011

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

द्वारा Tang, HaoRan, Leung, Leo, Saturno, Grazia, Viros, Amaya, Smith, Duncan, Di Leva, Gianpiero, Morrison, Eamonn, Niculescu-Duvaz, Dan, Lopes, Filipa, Johnson, Louise, Dhomen, Nathalie, Springer, Caroline, Marais, Richard
में प्रकाशित Nat Commun (2017)

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

द्वारा Tang, HaoRan, Leung, Leo, Saturno, Grazia, Viros, Amaya, Smith, Duncan, Leva, Gianpiero Di, Morrison, Eamonn, Niculescu-Duvaz, Dan, Lopes, Filipa, Johnson, Louise, Dhomen, Nathalie, Springer, Caroline, Marais, Richard
में प्रकाशित Nat Commun (2019)

A Novel, Selective and Efficacious Nanomolar Pyridopyrazinone Inhibitor of (V600E)BRAF

द्वारा Whittaker, Steven, Ménard, Delphine, Kirk, Ruth, Ogilvie, Lesley, Hedley, Douglas, Zambon, Alfonso, Lopes, Filipa, Preece, Natasha, Manne, Helen, Rana, Sareena, Lambros, Maryou, Reis-Filho, Jorge S, Marais, Richard, Springer, Caroline J
प्रकाशित 2010

Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma

द्वारा Girotti, Maria R, Pedersen, Malin, Sanchez-Laorden, Berta, Viros, Amaya, Turajlic, Samra, Niculescu-Duvaz, Dan, Zambon, Alfonso, Sinclair, John, Hayes, Andrew, Gore, Martin, Lorigan, Paul, Springer, Caroline, Larkin, James, Jorgensen, Claus, Marais, Richard
में प्रकाशित Cancer Discov (2012)

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth

द्वारा Smithen, Deborah A., Leung, Leo M. H., Challinor, Mairi, Lawrence, Rae, Tang, HaoRan, Niculescu-Duvaz, Dan, Pearce, Simon P., Mcleary, Robert, Lopes, Filipa, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Thomson, Graeme, Marais, Richard, Springer, Caroline
में प्रकाशित J Med Chem (2019)

Contrasting effects of sunitinib within in vivo models of metastasis

द्वारा Welti, Jonathan C., Powles, Thomas, Foo, Shane, Gourlaouen, Morgane, Preece, Natasha, Foster, Julie, Frentzas, Sophia, Bird, Demelza, Sharpe, Kevin, van Weverwijk, Antoinette, Robertson, David, Soffe, Julie, Erler, Janine T., Pili, Roberto, Springer, Caroline J., Mather, Stephen J., Reynolds, Andrew R.
प्रकाशित 2012

Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes

द्वारा Pedersen, Malin, Küsters-Vandevelde, Heidi V.N., Viros, Amaya, Groenen, Patricia J.T.A., Sanchez-Laorden, Berta, Gilhuis, Jacobus H., van Engen- van Grunsven, Ilse A., Renier, Willy, Schieving, Jolanda, Niculescu-Duvaz, Ion, Springer, Caroline J., Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A.M., Marais, Richard
प्रकाशित 2013

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships

द्वारा Leung, Leo, Niculescu-Duvaz, Dan, Smithen, Deborah, Lopes, Filipa, Callens, Cedric, McLeary, Robert, Saturno, Grazia, Davies, Lawrence, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Zambon, Alfonso, Chambers, Tim, Ménard, Delphine, Bayliss, Natasha, Knight, Ruth, Fish, Laura, Lawrence, Rae, Challinor, Mairi, Tang, HaoRan, Marais, Richard, Springer, Caroline
में प्रकाशित J Med Chem (2019)

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

द्वारा Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A., Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Takle, Andrew K., Wilson, David M., Pons, Jean-Francois, Coulter, Tom, Kirk, Ruth, Cantarino, Neus, Whittaker, Steven, Marais, Richard, Springer, Caroline J.
प्रकाशित 2010

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

द्वारा Miller, Bryan W, Morton, Jennifer P, Pinese, Mark, Saturno, Grazia, Jamieson, Nigel B, McGhee, Ewan, Timpson, Paul, Leach, Joshua, McGarry, Lynn, Shanks, Emma, Bailey, Peter, Chang, David, Oien, Karin, Karim, Saadia, Au, Amy, Steele, Colin, Carter, Christopher Ross, McKay, Colin, Anderson, Kurt, Evans, Thomas R Jeffry, Marais, Richard, Springer, Caroline, Biankin, Andrew, Erler, Janine T, Sansom, Owen J
में प्रकाशित EMBO Mol Med (2015)

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

द्वारा Girotti, Maria Romina, Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart M.J.M., Menard, Delphine, McLeary, Robert, Johnson, Louise, Fish, Laura, Ejiama, Sarah, Sanchez-Laorden, Berta, Hohloch, Juliane, Carragher, Neil, Macleod, Kenneth, Ashton, Garry, Marusiak, Anna A., Fusi, Alberto, Brognard, John, Frame, Margaret, Lorigan, Paul, Marais, Richard, Springer, Caroline
में प्रकाशित Cancer Cell (2015)

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

द्वारा Girotti, Maria Romina, Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart M.J.M., Menard, Delphine, McLeary, Robert, Johnson, Louise, Fish, Laura, Ejiama, Sarah, Sanchez-Laorden, Berta, Hohloch, Juliane, Carragher, Neil, Macleod, Kenneth, Ashton, Garry, Marusiak, Anna A., Fusi, Alberto, Brognard, John, Frame, Margaret, Lorigan, Paul, Marais, Richard, Springer, Caroline
में प्रकाशित Cancer Cell (2017)

RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

द्वारा Su, Fei, Viros, Amaya, Milagre, Carla, Trunzer, Kerstin, Bollag, Gideon, Spleiss, Olivia, Reis-Filho, Jorge S., Kong, Xiangju, Koya, Richard C., Flaherty, Keith T., Chapman, Paul B., Kim, Min Jung, Hayward, Robert, Martin, Matthew, Yang, Hong, Wang, Qiongqing, Hilton, Holly, Hang, Julie S., Noe, Johannes, Lambros, Maryou, Geyer, Felipe, Dhomen, Nathalie, Niculescu-Duvaz, Ion, Zambon, Alfonso, Niculescu-Duvaz, Dan, Preece, Natasha, Robert, Lídia, Otte, Nicholas J., Mok, Stephen, Kee, Damien, Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A., Wong, Bernice, Nguyen, Hoa, Kockx, Mark, Andries, Luc, Lestini, Brian, Nolop, Keith B., Lee, Richard J., Joe, Andrew K., Troy, James L., Gonzalez, Rene, Hutson, Thomas E., Puzanov, Igor, Chmielowski, Bartosz, Springer, Caroline J., McArthur, Grant A., Sosman, Jeffrey A., Lo, Roger S., Ribas, Antoni, Marais, Richard
प्रकाशित 2012