Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma

We generated cell lines resistant to BRAF inhibitors and show that the EGF receptor (EGFR)–SRC family kinase (SFK)–STAT3 signaling pathway was upregulated in these cells. In addition to driving proliferation of resistant cells, this pathway also stimulated invasion and metastasis. EGFR inhibitors co...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Girotti, Maria R, Pedersen, Malin, Sanchez-Laorden, Berta, Viros, Amaya, Turajlic, Samra, Niculescu-Duvaz, Dan, Zambon, Alfonso, Sinclair, John, Hayes, Andrew, Gore, Martin, Lorigan, Paul, Springer, Caroline, Larkin, James, Jorgensen, Claus, Marais, Richard
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321574/
https://ncbi.nlm.nih.gov/pubmed/23242808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0386
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki